{"id":488,"date":"2020-06-03T21:24:16","date_gmt":"2020-06-03T21:24:16","guid":{"rendered":"http:\/\/www.chinaiplawupdate.com\/?p=488"},"modified":"2021-03-08T05:10:46","modified_gmt":"2021-03-08T05:10:46","slug":"chinese-patent-application-for-coronavirus-vaccine-published","status":"publish","type":"post","link":"https:\/\/www.chinaiplawupdate.com\/2020\/06\/chinese-patent-application-for-coronavirus-vaccine-published\/","title":{"rendered":"Chinese Patent Application for Coronavirus Vaccine Published"},"content":{"rendered":"<p>The <a href=\"http:\/\/www.cnipa.gov.cn\/\">China National Intellectual Property Administration<\/a> published on June 2, 2020 what may be the first patent application covering a vaccine for the COVID-19 virus.\u00a0 The Institute of Military Medicine, Chinese Academy of Military Sciences in conjunction with <a href=\"http:\/\/www.cansinotech.com.cn\/\">CanSinoBIO<\/a>, a Chinese vaccine maker, filed application <a href=\"https:\/\/www.incopat.com\/detail\/init2?formerQuery=3eQEo0gaDThQKXKRZOStZWr4kAd0KKkg&amp;local=zh\">CN202010193587.8<\/a> on March 18, 2020 and is entitled &#8220;A new recombinant coronavirus vaccine using human replication-deficient adenovirus as a vector.&#8221;\u00a0 The patent application is based on research later <a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(20)31208-3\/fulltext\">published in the Lancet<\/a> showing their Ad5 vectored COVID-19 vaccine &#8220;is tolerable and immunogenic at 28 days post-vaccination.&#8221; The vaccine is the first candidate vaccine to begin<a href=\"http:\/\/newswire.ca\/news-releases\/the-national-research-council-of-canada-and-cansino-biologics-inc-announce-collaboration-to-advance-vaccine-against-covid-19-816213726.html\"> conducting Phase II human clinical trials<\/a>.<!--more--><\/p>\n<p>The patent application claims a polynucleotide, vector of the polynucleotide, adenovirus, and method of manufacturing the adenovirus.\u00a0\u00a0<\/p>\n<p>The unexamined claims follow:<\/p>\n<p>1. A polynucleotide for coding a S protein of the 2019 novel coronavirus is characterized in that the sequence of the polynucleotide is shown as SEQ ID NO: 1.<\/p>\n<p>2. A vector comprising the polynucleotide of claim 1.<\/p>\n<p>3. The vector of claim 2, wherein the vector is pDC316.<\/p>\n<p>4. A human replication-deficient recombinant adenovirus capable of expressing the polynucleotide of claim 1.<\/p>\n<p>5. The recombinant adenovirus of claim 4, wherein the recombinant adenovirus is derived from an admax adenovirus system.<\/p>\n<p>6. The use of the recombinant adenovirus of claims 4 and 5 in the preparation of a vaccine for the prevention of 2019 novel coronavirus.<\/p>\n<p>7. The method of claim 6, wherein the recombinant adenovirus is formulated as an injection, nasal drop, or spray.<\/p>\n<p>8. The use of claim 7, wherein the recombinant adenovirus is prepared as an intramuscular injection.<\/p>\n<p>9. A method of preparing a recombinant adenovirus according to claim 4 or 5, said method comprising the steps of: (1) constructing a shuttle plasmid vector comprising a polynucleotide encoding a 2019 novel coronavirus s protein; (2) transfecting the shuttle plasmid vector and the skeleton plasmid of step (1) into the host cell; (3) culturing the host cell in step (2); (4) harvesting the human replication-deficient recombinant adenovirus released from the cells of step (3); (5) amplifying and culturing the recombinant adenovirus in step (4); (6) purifying the culture product in step (5).<\/p>\n<p>10. The method of claim 9, wherein the vector of step (1) is pDC316.<\/p>\n<p>11. The method of claim 9, wherein the backbone plasmid of step (2) is pBHGlox_E1, 3Cre.<\/p>\n<p>12. The method of claim 9, wherein the cell of step (3) is an hek293 cell.<\/p>\n<p>13. The method of claim 9, wherein the amplification culture method of step (5) is suspension culture.<\/p>\n<p>14. The method of claim 9, wherein the purification method of step (6) is source 30q chromatography.<\/p>\n<p>There is no word yet on whether the application has or will be foreign filed.<\/p>\n","protected":false},"excerpt":{"rendered":"<p class=\"excerpt\">The China National Intellectual Property Administration published on June 2, 2020 what may be the first patent application covering a vaccine for the COVID-19 virus.\u00a0 The Institute of Military Medicine, Chinese Academy of Military Sciences in conjunction with CanSinoBIO, a Chinese vaccine maker, filed application CN202010193587.8 on March 18, 2020 and is entitled &#8220;A new recombinant coronavirus vaccine using human replication-deficient adenovirus as a vector.&#8221;\u00a0 The patent application is based on research later published in the Lancet showing their Ad5 &#8230;<\/p>\n<p class=\"more-link\"><a href=\"https:\/\/www.chinaiplawupdate.com\/2020\/06\/chinese-patent-application-for-coronavirus-vaccine-published\/\" class=\"button\">Continue Reading<\/a><\/p>","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"coauthors":[22],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - 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